YANG XIAOQING,VAN GOOR FREDRICK F,GROOTENHUIS PETER D.J.,NUMA MEHDI MICHEL JAMEL,BEAR BRIAN RICHARD,RUAH SARA S. HADIDA,MCCARTNEY JASON,ZHOU JINGLAN,MILLER MARK THOMAS
申请号：
NZ61148507
公开号：
NZ611485A
申请日:
2007.04.09
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed herein is a method for the preparation of an amide indole derivative compound of formula (Id) e.g. 1-(Benzo[d][1,3]dioxol-5-yl)-N-(2-(2-methyl-4-(1H-tetrazol-5-yl)butan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide or a pharmaceutically acceptable salt thereof for treating or lessening the severity of male infertility or pancreatic insufficiency, wherein the variables R1, R2, A, B and n shown in formula (Id) are as defined in the specification, and wherein the method comprises coupling the carboxylic acid moiety with an amine moiety as defined and shown in the specification.
