Ting XU,Aiwu ZHOU,Yuhao JIN,Ling WANG,Jie WU,Hongqin HU,Xiaoxiao WANG
申请号：
US16479858
公开号：
US20190352404A1
申请日:
2018.01.23
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to the field of medical biology, and discloses a high-resolution crystal structure of a complex of PD-L1-blocking heavy-chain single-domain antibody KNO35 binding with PD-L1, and the use of the crystal structure. The invention also relates to novel PD-L1 binding polypeptides or compounds developed based on the crystal structure and uses thereof.
