BLANCO-PILLADO, MARIA-JESUS,COHEN, MICHAEL,FILLA, SANDRA,HUDZIAK, KEVIN,KOHLMAN, DANIEL,BENESH, DANA,VICTOR, FRANTZ,XU, YAO-CHANG,YING, BAI-PING,ZACHERL, DEANNA,ZHANG, DEYI,MATHES, BRIAN MICHAEL
申请号：
ES04780442
公开号：
ES2379665T3
申请日:
2004.09.03
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Compound of formula I: or a pharmaceutically acceptable acid addition salt thereof, wherein； X is -C (R3c) = or -N =； R1 is phenyl, substituted phenyl, heterocycle or substituted heterocycle, in which the heterocycle is selected from the group consisting of pyridinyl, thiophenyl and furanyl and in which substituted phenyl means that the ring moiety is: i. substituted with one to three halogen substituents； or ii. substituted with one to two substituents independently selected from the group consisting of halogen, methyl, methoxy, trifluoromethyl, trifluoromethoxy and cyano； and in which substituted heterocycle means that the ring moiety is monosubstituted with halogen； R2 is hydrogen； n-C1-C3 alkyl, cycloalkyl-C3-C6-C1-C3 alkyl, or a group of formula II R3a, R3b and, when X is -C (R3c) =, R3c, are each independently hydrogen, fluorine or methyl provided that no more than one of R3a, R3b and R3c may be other than hydrogen； R4 is hydrogen； and R5 is hydrogen or methyl, provided that when R3a is other than hydrogen, R5 is hydrogen； R6 is hydrogen or C1-C6 alkyl； and n is an integer from 1 to 6 inclusive.Compuesto de fórmula I: o una sal de adición de ácido farmacéuticamente aceptable del mismo, en la que； X es -C (R3c) = o -N=； R1 es fenilo, fenilo sustituido, heterociclo o heterociclo sustituido, en los que el heterociclo se selecciona del grupo que consiste en piridinilo, tiofenilo y furanilo y en los que fenilo sustituido significa que el resto de anillo está: i. sustituido con de uno a tres sustituyentes halógeno； o ii. sustituido con de uno a dos sustituyentes seleccionados independientemente del grupo que consiste en halógeno, metilo, metoxilo, trifluorometilo, trifluorometoxilo y ciano； y en los que heterociclo sustituido significa que el resto de anillo está monosustituido con halógeno； R2 es hidrógeno； n-alquilo C1-C3, cicloalquil-C3-C6-alquilo-C1-C3, o un grupo de fórmula II R3a, R3b y, cuando X es -C (R3c) =, R3c, son cada uno independientemente hidrógeno, f
