The present application discloses systems, methods, and articles of manufacture for characterizing hearing prosthesis channel interaction. Some embodiments may include applying a probe signal to a region of auditory neurons via a first hearing prosthesis channel, and applying a perturber signal to the region of auditory neurons via a second hearing prosthesis channel, where the perturber signal is configured to cause a polarity-independent neural excitation in an auditory neuron. Some embodiments may additionally include measuring one or more metrics corresponding to a neural response to the application of the probe and perturber signals.