Systems and methods for personalizing prosthetic and orthotic devices are disclosed. In some embodiments, a method of personalizing a portion of a device configured to be worn by a wearer as at least one of a prosthetic or an orthosis may include facilitating an application of a wearer-selected artwork to the portion of the device. For example, in various specific embodiments, the facilitating an application of a wearer-selected artwork to the portion of the device may include creating a portion of material having a wearer-specified personalization artwork, and providing the portion of material having the wearer-specified personalization artwork to at least one of the wearer or a third party for application onto the portion of the device. In some embodiments, the portion of material may be provided to at least one of the wearer or a third party for application when the portion of the device is being fabricated.