The Brigham and Women's Hospital, Inc.;President and Fellows of Harvard College;Massachusetts Institute of Technology;The Children's Medical Center Corporation
发明人:
Ulrich H. von Andrian,Omid C. Farokhzad,Robert S. Langer,Tobias Junt,Elliott Ashley Moseman,Liangfang Zhang,Pamela Basto,Matteo Iannacone,Frank Alexis
申请号：
US16544464
公开号：
US20200054559A1
申请日:
2019.08.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
