A solution of erythritol and water, saturated at a desired therapeutic temperature, is contained in a hot water bottle, or other appropriate vessel, for the purpose of therapeutic warming, for example, for the relief of gastro-intestinal or muscular discomfort. The heat of crystallization of the erythritol significantly extends the time of therapeutic warming. Nucleation agents are added to delay the formation of large crystals upon cooling of the solution. The resulting product is non-toxic to humans and to canines.