HOLSAPPLE, EARLE T,PARCHMENT, RALPH E,BOINPALLY, RAMESH R,ROSE, STEVEN E,JASTI, BHASKARA R
申请号：
NZ57260107
公开号：
NZ572601A
申请日:
2007.03.29
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a lipid nanoparticlc composition comprising a neutral retinoid and a lipid component, wherein (a) the retinoid is dispersed in nanoparticles having diameters of less than or equal to about 1000 nm； (b) the final concentration of the retinoid is between about 4 and about 75 mg/ml. (e) the lipid component excludes any cholesterol or animal-derived lecithin and is (i) a plant-derived lecithin acceptable for use in mammals in vivo； or (ii) phospholipids of said lecithin of (i)； or (iii) cholic acid or a salt thereof and one or more synthetic, chemically-defined phospholipids having two fatty acid chains； or (iv) one or more synthetic chemically-defined phospholipids having two fatty acid chains wherein the nanoparticles have a surface charge characterized by a zeta potential of between about -50 millivolts to about + 11 millivolts； and which composition is free of non- ionic surfactants, detergents, polyoxylated compounds, alkoxylated oils or any animal-derived substance known to be allergenic or to induce an anaphylactic reaction when administered to a human
