ШЕФЕРД Бенджамин Р. (US),ПРЕСНЕЛЛ Шэрон С. (US),ЭВИНГЕР Альберт Дж. III (US)
申请号：
RU2015100977
公开号：
RU2015100977A
申请日:
2013.06.19
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. Engineered living three-dimensional construct of connective tissue, comprising: a connective tissue cells associated with each other due to the cohesive forces to produce live, three-dimensional connective tissue construct wherein the construct comprises substantially no preformed frame when ispolzovaniya.2. The construct according to Claim. 1, wherein the construct is not innervirovannym.3. The construct according to Claim. 1, wherein the connective tissue cells comprise cells obtained in vitro from connective tissue multipotent kletok.4. . The construct of claim 3, wherein the multipotent cells contain one or more of the following: tissue-specific precursors, mesenchymal stem / stromal cells, induced pluripotent stem cells and embryonic stem kletki.5. The construct of claim. 3, wherein the multipotent cells are derived from adipose tissue mlekopitayuschih.6. The construct of claim. 3, wherein the multipotent cells are derived from bone marrow mlekopitayuschih.7. The construct of claim. 3, wherein the multipotent cells are derived from a source not lean tissue from the bone mozga.8. The construct of claim. 3, wherein the multipotent cells are subjected to one or more signals to manufacture konstrukta.9 differentiation. The construct of claim. 3, wherein the multipotent cells are subjected to one or more differentiation signals in the manufacture konstrukta.10. The construct of claim. 3, wherein the multipotent cells are subjected to one or more signals konstrukta.11 differentiation after manufacture. The construct of claim. 1, where the construct prepared bioprintingom.12. The construct of claim. 11, further comprising:1. Спроектированный, живой, трехмерный конструкт соединительной ткани, содержащий: клетки соединительной ткани, ассоциированные друг с другом благодаря силам когезии для получения живого, трехмерного конструкта соединительной ткани причем данный конструкт по существу не содержит предварительно образованный каркас в момент использования.2. Конструк
