Sunghoon Kim,Jin Woo Choi,Jin Young Lee,Dae Gyu Kim,Gyoon Hee Han,Jee Sun Yang,Chul Ho Lee
申请号：
US13465709
公开号：
US20120283300A1
申请日:
2012.05.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This application relates to a novel benzo-heterocycle derivative and more particularly, it relates a composition for preventing and treating cancer or for inhibiting metastasis comprising benzo-heterocycle derivative or pharmaceutically acceptable salts thereof as an active ingredient. The present inventors confirmed that KRS has an effect on cancer metastasis by facilitating cancer (or tumor) cell migration through interaction with 67LR, and also found that a substance inhibiting the interaction between KRS and 67LR can prevent and treat cancer by inhibiting cancer cell metastasis. Accordingly, the composition of the present invention can inhibit cancer metastasis, and thus provide a novel means for prevention and treatment of cancer.
