The invention refers to a synergistic combination comprising a Sigma ligand, particularly a Sigma ligand of general formula (I), and NSAID compound, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament, particularly for the prophylaxis and/or treatment of pain.本發明關於一種增效組合,其包含西克馬(Sigma)配位體(特別是通式(I)之西克馬配位體)與NSAID化合物,一種包含該活性物質組合之藥劑,及該活性物質組合用於製造藥劑(特別是供疼痛的預防及/或治療者)之用途。