process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz / b, f / azepine-5-carboxamide, process for the preparation of 10,11-dihydro-10-oxo-5h-dibenz / b, f / azepine-5-carboxamide and process for the preparation of 10-acetoxy-10,11-dihydro-5h-dibenz / b, f / azepine-5-carboxamide
David Alexander Learmonth,GÜNTER WEINGÄRTNER,Matthias Kraemer
申请号：
BRPI0606252
公开号：
BRPI0606252A8
申请日:
2006.01.13
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz / b, f / azepino-5-careoxanide, process for the preparation of 10,11-dihydro-10-oxo-5h-dibenz / b, f / azepine-5-carboxamide and process for the preparation of 10-acetoxy-10,11-dihydro-5h-dibenz / b, f / azepine-5-carboxamide. Process for the preparation of 1α, 11-dihydro-10-hydroxy-5h-dibenz / b, f / azepine-5-carboxamide (1) through ring opening of 11a, lob-dihydro-6h-dibenz / b, f oxirene 1d] azepine-6-carboxamide (5), wherein the ring opening is conducted under high pressure conditions.processo para a preparação de 10,11-dihidro-10-hidroxi-5h-dibenz/b,f/azepino-5-careoxanida, processo para a preparação de 10, 11-dihidro-10-oxo-5h-dibenz/b,f/azepino-5-carboxamida e processo para a preparação de 10-acetoxi-10, 11-dihidro-5h-dibenz/b,f/azepino-5-carboxamida. processo para a preparação de 1o,ll-dihidro-10-hidroxi-5h-dibenz/b, f/azepino-5-carboxamida (1) através de abertura de anel de lia, lob-dihidro-6h-dibenz/b, f/oxireno ld] azepino-6-carboxamida (5), sendo que a abertura de anel é conduzida sob condições de pressão elevada.
