The United States of America; as Represented by the Secretary; Department of Health & Human Services
发明人:
Plenz, Dietmar,Shriki, Oren,Tononi, Giulio,Meisel, Christian
申请号：
AU2014306458
公开号：
AU2014306458A1
申请日:
2014.08.15
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention is directed to a method of continuously monitoring neuronal avalanches in a subject comprising (a) determining a deviation in avalanche exponent (a) or branching parameter (σ) from a predetermined value at rest, wherein the pre-determined value of a is a slope of a size distribution of the synchronized neuronal activity and the predetermined value is -3/2 and the pre-determined value of σ is a ratio of successively propagated synchronized neuronal activity and the predetermined value is 1 and (b) repeating step (a) one or more times to continuously monitor neuronal avalanches in a subject. The invention also features methods of determining or monitoring the degree of sleep deprivation in a subject, methods of identifying subjects that are susceptible to a sleep disorder and methods of diagnosing a sleep disorder in a subject.
