COMPOSES (4'-HYDROXYPHENYL)CYCLOALCANE ET (4'-HYDROXYPHENYL)CYCLOALCENE SUBSTITUES ET LEURS UTILISATIONS EN TANT QU'AGONISTES SELECTIFS DE L'ISOFORME BETA DU RECEPTEUR DES OESTROGEN NES POUR UNE CONSOLIDATION AMELIOREE DE MEMOIRE
MARQUETTE UNIVERSITY;CONCORDIA UNIVERSITY, INC.;UWM RESEARCH FOUNDATION, INC.
发明人:
DONALDSON, WILLIAM A.,SEM, DANIEL S.,FRICK, KARYN
申请号：
CA3057369
公开号：
CA3057369A1
申请日:
2018.03.30
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed are substituted (4'-hydroxylphenyl)cycloalkane compounds and substituted (4'-hydroxylphenyl)cycloalkene compounds and there use as selective agonists of the estrogen receptor beta isoform (ERß). The disclosed compounds may be formulated as pharmaceutical compositions and administered for treating diseases associated with ER activity, such as neurological, psychiatric, and/or cell proliferative diseases and disorders as well as for enhancing memory consolidation in subjects in need thereof.
