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PIRROLO DERIVATIVES [2,3-C] PIRIDINE AND PROCESSES FOR PREPARATION.
专利权人:
YUHAN CORPORATION
发明人:
KIM, JAE-GYU,AHN, BYUNG-NAK,LEE, HYOUK-WOO,YOON, SUK-WON,YOON, YOUNG-AE,KIM, DONG-HOON,PARK, CHAN-SUN,HAN, SEOK-HEE,CHA, MYUNG-HUN,KANG, HEUI-IL,CHOI, RYONG
申请号:
ES05808813
公开号:
ES2373672T3
申请日:
2005.09.03
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of the formula (I) or a pharmaceutically acceptable salt thereof: wherein: R1 is hydrogen; a linear or branched C1-C7 alkyl group, optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, cyano, C3-C7 cycloalkyl, C1-C5 alkoxy, C1-C5 alkoxycarbonyl, linear C1-C5 alkylcarbonyloxy or branched, C1-C3-alkoxy-C1-C3 alkoxy, C1-C3 alkylsulfanyl, C2-C5 alkenyloxy, formyl, pyridyl, naphthyl, thiazolyl (the thiazole ring is optionally substituted with one or more C1-C3 alkyl), thiophenyl (the thiophene ring is optionally substituted with one or more halogen), isoxazolyl (the isoxazol ring is optionally substituted with one or more C1-C3 alkyl), 1,3-dioxolanyl (the 1,3-dioxolane ring is optionally substituted with one or more C1-C3 alkyl), 1,3-dioxanyl, oxyranyl and tetrahydropyranyl; a C2-C6 alkenyl group optionally substituted with phenyl; a linear or branched C2-C6 alkynyl group; a C3-C6 dienyl group; or a group - (CH2) p-phenyl (p is 0, 1, 2 or 3 and the phenyl ring is optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, a linear C1-C5 alkyl or branched, C1-C3 alkoxy, C1-C3 alkoxycarbonyl, C1-C3 trifluoroalkyl, C1-C3 trifluoroalkoxy and C1-C3 alkylsulfonyl), R2 is a linear or branched C1-C6 alkyl group, R3 is hydrogen; a linear or branched C1-C6 alkyl group, optionally substituted with one or more substituents selected from the group consisting of hydroxy, C1-C5 alkoxy, C1-C3 alkylcarbonyloxy, cyano, morpholinyl and mono-, di- or trialkylamino-C1- C3; a halogen group; a cyano group; a formal group; a C1-C3 alkylsulfanyl group; a C1-C3 alkylsulfonyl group; or a C1-C3 alkylsulfinyl group, R4 is hydrogen; a linear or branched C1-C6 alkyl group, optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, cyano, amino, C1-C5 alkylamino, C3-C6 cycloalkylamino, phenylamino (the phenyl ring is optionally substituted wi
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