Kristin K. H. Neuman,Jonathan Miles Brown,Hans-Peter Vornlocher
申请号：
US15889975
公开号：
US20180223284A1
申请日:
2018.02.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to methods of administering to a subject multimeric oligonucleotides having monomeric subunits joined by linkers. The multimeric oligonucleotides have a molecular weight of at least about 45 kD and other characteristics, such that their clearance due to glomerular filtration is reduced. The present invention also relates to such multimeric oligonucleotides and methods of synthesizing such multimeric oligonucleotides.
