compound of formula, pharmaceutical composition, method of inhibiting tgf-b signaling pathways or activating or both, in human, method of treating, preventing, or reducing tumor cell metastasis in human, method of treating, preventing, reducing mediated carcinomas by over-expression of tgf-b by inhibiting a tgf-b signaling pathway in a human, method of treating, preventing or reducing vascular injury in a human, and method for treating, preventing or reducing disease in a human
This invention relates to 2-pyridyl substituted imidazoles (I) which are inhibitors of the transforming growth factor-² (TGF-²) type I receptor (ALK5) and/or the activin type I receptor (ALK4), methods for their preparation, and their use in medicine, specifically in the treatment and prevention of a disease state mediated by these receptors.
