The present invention relates to a colitis inhibitor which is safe and exhibits an excellent colitis inhibition effect, and a method for producing same. More specifically, the present invention relates to a colitis inhibitor that contains, as an active ingredient, lactic acid bacteria of the genus Lactobacillus, the lactic acid bacteria exhibiting heat shock protein (HSP) 70 expression-promoting activity in colonic cells.本發明係關於安全且具有優異的大腸炎抑制效果之大腸炎抑制劑及其製造方法。更詳細而言,本發明係關於以具有大腸細胞中之熱休克蛋白(HSP)70的表現增強活性之乳酸桿菌屬乳酸菌作為有效成分之大腸炎抑制劑。