Piepoli, Tiziana,Mandelli, Stefano,Mazzari, Silvio,Verpilio, Ilario,Tarchino, Francesca,Rovati, Lucio Claudio,Giordani, Antonio,Caselli, Gianfranco,Zanzola, Simona,Makovec, Francesco
申请号：
AU2006346931
公开号：
AU2006346931B2
申请日:
2006.08.03
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention is directed to novel 6-lH-imidazo-2- aryl and 2-heteroarylquinazoline and quinoline of Formula (I), corresponding salts and solvatesthereof, to a process for their preparation and to the use of this compounds andcorresponding pharmaceutical composition for the treatment of pain and inflammatoryrelated disorders. Compounds of the invention have been proven highly effectivein the pharmacological treatment of both inflammatory and neuropathic pain,in addition to striking anti-inflammatory properties. Their effectivenessin interfering with COX-2 and inflammatory cytokines expressions and production,highlights them as interesting compounds also for the treatment of cancer inaddition to several inflammatory diseases.
