The present invention relates to a composition, especially pharmaceutical composition, preferably in the form of a lubricant gel and/or lubricant medium, preferably for use as a (local) antiseptic and/or (local) anaesthetic, especially for use in diagnostic and/or therapeutic (operative) interventions, preferably for use in catheterizations, preferably transurethral or suprapubic catheterizations, exploratory procedures, endoscopies, intubations and/or interventions to aid birth, wherein the composition in each case contains effective, especially pharmaceutical active, amounts of at least one local anaesthetic and polyhexanide and/or salts thereof, especially as antiseptic active ingredient and/or constituent (disinfectant).