Acton, Paul,Zhiqiang, An,Bett, Andrew J.,Robert, Breese,Dodson, Elizabeth Chen,Kinney, Gene,Liang, Xiaoping,Shughrue, Paul,Viola, Kirsten L.,Strohl, William R.
申请号：
AU2011204912
公开号：
AU2011204912B2
申请日:
2011.07.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011204912B220120510.pdf#####Abstract: The present invention relates to antibodies that differentially recognize multi-dimensional conformations of AP-derived diffusible ligands, also known as ADDLs. The antibodies of the 5 invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods .0 for the preventing and treating diseases associated with soluble oligomers of amyloid @ 1-42.
