The present invention relates to dermatological compositions comprising heparan sulfate. The heparan sulphate for use in the compositions of the invention has molecular weight by weight comprised between 6,000 Da and 12,000 Da. The dermatological compositions according to the invention comprise heparan sulphate in an amount comprised between 0.01 wt% and 5 wt%. The dermatological compositions according to the invention show, inter alia, lenitive effect.