LI, TIECHAO,POBANZ, MARK, ANDREW,SHIH, CHUAN,WU, ZHIPEI,YANG, WEI JENNIFER,ZHONG, BOYU
申请号：
NZ59001309
公开号：
NZ590013A
申请日:
2009.07.15
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is an amidophenoxyindazole compound of structural formula depicted herein and its pharmaceutically acceptable salt, wherein: R1 is H or methyl R2 is amino, dimethylamino, fluoro, cyclopropyl, pyridyl optionally substituted with an amino substituent or 1-2 methyl substituents, pyrazolyl optionally substituted with two methyl substituents, 2-methoxy-pyrimidin-5-yl, 4-methylsulfonylphenyl, tetrahydro-2H-pyran-4-ylamino, (tetrahydro-2H-pyran-4-yl)amino carbonyl, or a morpholin-4-yl substituent as defined in the specification. These compounds are useful as inhibitors of c-Met and are suitable for treating cancer selected from the group consisting of lung cancer, breast cancer, colorectal cancer, renal cancer, pancreatic cancer, head cancer, neck cancer, hereditary papillary renal cell carcinoma, childhood hepatocellular carcinoma, and gastric cancer.
