Omega-aminoalkylamides of (R) -2-aryl-propionic acids as inhibitors of polymorphonuclear and mononuclear cell chemotaxis, their preparation process, and pharmaceutical composition

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专利权人:

DOMPE' S.P.A.;DOMPÉ FARMACEUTICI S.P.A;DOMPÉ pha.r.ma s.p.a.;Dompé S.P.A.

发明人:

Carmelo Candolfi,Cinzia Bizzarri,Francesco Colotta,Gianfranco Caselli,Marcello Allegretti,Maria Candida Cesta,Riccardo Bertini,Valerio Berdini,Vito Di Cioccio

申请号：

BRPI0207664

公开号：

BRPI0207664B1

申请日:

2002.02.25

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

"Omega-aminoalkylamides of r-2-aryl propionic acids as inhibitors of polymorphonucleated and mononucleated cells chemotaxis". The patent relates to (r) -2-arylpropionamide compounds of formula (I) which are described. The process for their preparation and pharmaceutical preparations thereof are also described. The 2-arylpropionamides of the invention are useful in preventing and treating tissue damage due to exacerbated recruitment of polymorphonucleated leukocytes (pmn leukocytes) and monocytes at the inflammation sites. in particular, the invention relates to the 2-aryl propionic acid omega-aminoalkylamide enanciomers of formula (I) for use in inhibiting the complement fraction c5a neutrophil and monocyte chemotaxis and other chemotactic proteins whose Biological activity is associated with activation of a 7-td receptor. Selected compounds of formula (I) are dual inhibitors of c5a-induced neutrophil and monocyte chemotaxis and pmn-8-induced leukocyte chemotaxis. The compounds of the invention are used in the treatment of psoriasis, ulcerative colitis, glomerular nephritis, acute respiratory failure, idiopathic fibrosis, rheumatoid arthritis, and the prevention and treatment of ischemia and reperfusion damage."ômega-aminoalquilamidas de ácidos r-2-aril-propiônico como inibidores da quimiotaxia de células polimorfonucleadas e mononucleadas". a patente de invenção refere-se a compostos de (r)-2-arilpropionamida da fórmula (i) que são descritos. o processo para sua preparação e preparações farmacêuticas dos mesmos também são descritos. as 2-arilpropionamidas da invenção são úteis na prevenção e tratamento de dano tecidual devido ao recrutamento exacerbado de leucócitos polimorfonucleados (leucócitos pmn) e de monócitos nos locais de inflamação. em particular, a invenção refere-se aos enanciômeros r de ômega-aminoalquilamidas de ácidos 2-aril propiônicos, da fórmula (i), para uso na inibição da quimiotaxia de neutrófilos e monócitos induzida pela fração c5a do compleme

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/