A bed rest system for improving health of immobile patients and safety of the patients caretakers. The system includes a mattress cover and a transfer board. The mattress cover is configured to prevent or ameliorate health complications of a patient that may arise because of bed rest. The transfer board is configured to facilitate easy and safe transfer of a patient from one surface to another surface by one or more caretakers. During use, the mattress cover conforms to a patients body and does not cause indentations in the skin, thereby preventing or ameliorating bedsores. During use, the transfer board is secured on a crevice between two surfaces, such as beds, and prevents or reduces a risk of the patient falling between the beds during transfer of the patient from one bed to the other bed. The complete system may be used, or either the mattress cover or the transfer board may be used individually.
