Methods and devices are provided for delivering a preloaded loop of suture extending from a knotting element to tissue to be ligated within a body. The knotting element can be threaded with a loop of suture and loaded onto a deployment device using a loading device. A protective sheath can be placed around the knotting element and the loop of suture to facilitate safe insertion of the loop of suture through a working channel of a minimally invasive device.
