Mario Varasi,Florian Thaler,Agnese Abate,Giacomo Carenzi,Ciro Mercurio,Saverio Minucci
申请号：
US12988197
公开号：
US08592444B2
申请日:
2009.04.14
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention is related to new histone deacetylase inhibitors according to the general formula (I) wherein: the dotted line is an optional additional bond； n is zero or an integer from 1 to 4； R1 is hydrogen； C1-C6 alkyl, optionally substituted by cycloalkyl, aryl or by heteroaryl； (CO)R3； (SO2)R4； cycloalkyl； aryl； or heteroaryl； R2 is C1-C6 alkyl, optionally substituted by aryl or by heteroaryl； aryl； heteroaryl； or (CO)R5； X is CH2, oxygen or NR6； Y is a bond, CHR7 or NR8； Z is oxygen, CR9R10 or C═R11； and R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as further defined in the specification； and pharmaceutical acceptable salts thereof.
