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CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONOTHIOLATES AND -PHOSPHONATES
专利权人:
FORSCHUNGSVERBUND BERLIN E.V.;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
发明人:
HACKENBERGER, Christian,BAUMANN, Alice Leonie,KASPER, Marc-André,BYRNE, Stephen,HELMA-SMETS, Jonas,LEONHARDT, Heinrich,STOSCHECK, Tina,GERLACH, Marcus,SCHUMACHER, Dominik
申请号:
SG11202008186R
公开号:
SG11202008186RA
申请日:
2019.03.06
申请国别(地区):
SG
年份:
2020
代理人:
摘要:
Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene-or alkyne-phosohonothiolates and -phosphonates comprises the step of: reacting a compound of formula (I) with a thiol-containing molecule of formula (II) wherein represents an amino acid, a peptide, a protein, an antibody, a nucleotide, an oligonucleotide, a saccharide, a polysaccharide, a polymer, an optionally substituted C1-C8-alkyl, an optionally substituted phenyl, or an optionally substituted aromatic 5-or 6- membered heterocyclic system; resulting in a compound of formula (III)..
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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