Byoung S Kwon,Seoung-Joo Lee,Joong Won Lee,Seunghyun Lee
申请号：
US16255690
公开号：
US20190233535A1
申请日:
2019.01.23
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided are IFN-y-Inducible Regulatory T Cell Convertible Anti-Cancer (IRTCA) antibodies and antigen-binding fragment thereof that bind to an activation-inducible TNFR (AITR) polypeptide. Various in vitro and in vivo methods and compositions related to IRTCA antibodies described herein are also provided. Methods include, for example, changing cytokine secretion from T cells in vivo or in vitro and prevention and/or therapeutic treatment of cancer using an IRTCA antibody or fragment thereof.
