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DERIVES D'INDOLE EN TANT QU'ANTAGONISTES DU RECEPTEUR CRTH2
专利权人:
MERCK CANADA INC.
发明人:
申请号:
EP06775085.1
公开号:
EP1915372B1
申请日:
2006.08.07
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
Compounds according to formula (I) wherein the radicals R1, R2 and R3 are as herein defined, and wherein Ar represents an aryl group or heteroaryl group, preferably phenyl, n is 1 or 2, and the radical X represents a group selected from —C(Ra)(Rb)—, —C(Ra)(Rb)—C(Ra)(Rb)—, —C(Ra)═C(Ra)—, OC(Ra)(Rb)— or SC(Ra)(Rb)—. These compounds and their pharmaceutical acceptable salts are used in pharmaceutical compositions as prostaglandine D2 receptor antagonists useful in the treatment of CRTH2-mediated diseases such as respiratory, inflammatory or allergic conditions among others.
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