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RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF HER3
专利权人:
ENZON PHARMACEUTICALS; INC.
发明人:
HEDTJARN, MAJ
申请号:
NZ58120108
公开号:
NZ581201A
申请日:
2008.05.09
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed are oligomeric compounds (oligomers), which target HER3 mRNA in a cell, leading to reduced expression of HER3 and/or HER2 and/or EGFR. Reduction of HER3 and/or HER2 and/or EGFR expression is beneficial for a range of medical disorders, such as hyperproliferative diseases, including cancer. The invention provides therapeutic compositions comprising oligomers and methods for modulating the expression of HER3 and/or HER2 and/or EGFR using said oligomers, including methods of treatment.
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