Shanghai Institute of Materia Medica, Chinese Academy of Sciences;Zhejiang University
发明人:
申请号：
EP17869906.2
公开号：
EP3530656A4
申请日:
2017.11.08
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
A 2-substituted aromatic ring-pyrimidine derivative as shown in a general fomula I, and an optical isomer or a pharmaceutically acceptable salt or a solvate thereof are provided. The present invention designs and synthesizes a series of novel small molecular Chkl inhibitors by using-substituted pyridin-2-aminopyrimidine obtained through structure-based virtual screening as a lead compound, and carries out Chkl kinase inhibitory activity test. The experiment confirmed that said compounds possess strong anti-cancer effect, Chkl kinase inhibitory activity and are promising Chkl inhibitors. The compounds can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal.
