Jason G. Lewis,Nicholas Reich,Tao Chen,Jeffrey W. Jacobs,Dominique Charmot,Marc Navre,Patricia Finn,Christopher Carreras,Andrew Spencer
申请号：
US14310989
公开号：
US20150148311A1
申请日:
2014.06.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compounds having the following structure (I):or a stereoisomer, tautomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, R3, R4, R8, R9, R10, R11, R12, A1, A2, X, Y and Z are as defined herein. Uses of such compounds as TGR5 antagonists and for treatment of various indications, including Type II diabetes meletus are also provided.
