Marina Rautenbach,Abré De Beer,Anscha Mari Troskie,Johan Arnold Vosloo
申请号：
US14380518
公开号：
US20150030566A1
申请日:
2013.08.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compositions containing one or more tyrocidines, tryptocidines, phenycidines and/or gramicidin S, or derivatives and analogues thereof, are described for controlling antimicrobial growth on plants, plant material or plant growth media, and methods for controlling or preventing the growth of microbial pathogens, and in particular fungal pathogens, on plants, plant parts and plant material are described herein. The active agents used to control these pathogens are tyrocidines, tryptocidines, phenycidines and/or gramicidin S, or derivatives, analogues or modifications thereof. The tyrocidines, tryptocidines, phenycidines and/or gramicidin S are cyclic decapeptides having the general amino acid sequence cyclo(valine-Xrleucine-D-phenylalanine-proline-X2-X3-X4-X5-X6) (SEQ ID NO: 1) or a derivative or analogue thereof, wherein X1 is ornithine or lysine, X2 is valine, leucine, isoleucine, phenylalanine, tryptophan or tyrosine； X3 is the D-isomer of valine, leucine, isoleucine, phenylalanine, tryptophan, tyrosine, ornithine, or lysine； X4 is asparagine, glutamine or leucine； X5 is glutamine, the D-isomer of valine, leucine, or isoleucine； and X6 is tyrosine, phenylalanine, tryptophan or proline.
