Hendri Tjandra;Jianmin Chen;Thomas Barnett;Liang Tang;Clark Q. Pan;Jonathan S. Strauss;John E. Murphy;Baisong Mei;Deqian Wang
发明人:
Clark Q. Pan,John E. Murphy,Baisong Mei,Jonathan S. Strauss,Hendri Tjandra,Jianmin Chen,Thomas Barnett,Liang Tang,Deqian Wang
申请号：
US12540703
公开号：
US09364520B2
申请日:
2009.08.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
