The present invention relates to a composition comprising at least one biological control agent selected from the group consisting of Bacillus pumilus (NRRL Accession No. B-30087), Bacillus subtilis AQ713 (NRRL Accession No. B-21661), Bacillus subtilis AQ30002 (NRRL Accession No. B-50421), and Bacillus subtilis AQ 30004 (NRRL Accession No. B-50455) and/or a mutant of these strains having all the identifying characteristics of the respective strain, and/or a metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens and at least one insecticide which is a microbial disruptor of insect midgut membranes, in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.