BLASKOVICH, MARK, ARNOLD, THOMAS,CASSIDY, PETER, JOSEPH
申请号：
NZ58736109
公开号：
NZ587361A
申请日:
2009.02.27
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is the use of compounds of formula (I) and salts thereof for the treatment of acne, seborrhoea (seborrhea) and seborrheic dermatitis. Compounds of formula (I) down-regulate the activity of the melanocortin-5 receptor (MC5R). Specific examples of compounds of formula (I) include: N-(((3S,5S)-1-(3,5-dichlorobenzyl)-3-(3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)methyl)-2-naphthamide, N-(((3S,5S)-1-(2,2-diphenylethyl)-3-(3-(isopropylamino)propyl)-2-oxo-1,4-diazepan-5-yl)methyl)-2-naphthamide, N-(((3S,5S)-1-(2,2-diphenylethyl)-3-(3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)methyl)isoquinoline-3-carboxamide, N-(((3S,5S)-1-(2,2-diphenylethyl)-3-(3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)methyl)benzofuran-2-carboxamide, and 3,4-dichloro-N-(((3S,5S)-3-(2-(4,4-difluoropiperidin-1-yl)ethyl)-2-oxo-1-((S)-2-phenylbutyl)-1,4-diazepan-5-yl)methyl)benzamide
