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Lingo-2 antagonists for treatment of conditions involving motor neurons
专利权人:
Biogen MA Inc.
发明人:
Mi Sha,Pepinsky R. Blake
申请号:
NZ70217813
公开号:
NZ702178A
申请日:
2013.05.14
申请国别(地区):
NZ
年份:
2017
代理人:
摘要:
The invention provides methods of treating diseases, disorders or injuries involving motor neuron survival and axonal growth, including amylotrophic lateral sclerosis, by the administration of a LINGO-2 antagonist. An exemplary method for promoting survival of a motor neuron, comprising contacting said motor neuron with an effective amount of a composition comprising a LINGO-2 antagonist selected from the group consisting of: (i) a soluble LINGO-2 polypeptide; (ii) a LINGO-2 antibody or antigen-binding fragment thereof; (iii) a LINGO-2 antagonist polynucleotide; (iv) a LINGO-2 aptamer; and (v) a combination of two or more of said LINGO-2 antagonists.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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