TISSUE TRANSPLANTATION INVOLVING, AND TISSUES MODIFIED BY DECELLULARIZATION AND RECELLULARIZATION OF DONOR TISSUES FOR MINIMIZED OR OBVIATED REJECTION REACTIONS.
A kidney was removed from a donor animal (a pig) and was later transplanted into a recipient animal (another, non-familial pig). The procedure produced a functioning kidney (actively producing urine) in the recipient, without rejection or the formation of scar tissue after two weeks post-transplantation. The procedure involves decellularization of the donor organ, followed by recellularizing the donor organ with cells grown from the recipients stem cells through use of cytokines, or "growth factors", that are extracted from the recipients blood plasma.Un riñón se extrajo de un animal donador (un cerdo) y se trasplantó posteriormente en un animal receptor (otro cerdo sin parentesco). El procedimiento produjo un riñón funcional (que produce activamente la orina) en el receptor, sin el rechazo o la formación de tejido cicatrizado después de dos semanas posteriores al trasplante. El procedimiento implica la descelularización del órgano donador, seguida por la recelularización del órgano donador con las células desarrolladas a partir de las células madres del receptor a través del uso de citosinas, o "factores de crecimiento", que se extraen del plasma sanguíneo de receptor.
