The present disclosure provides systems and methods for performing multi-parametric diagnosis for liver disease. The present disclosure provides systems and methods that include: positioning a subject, for example a patient, in association with a medical imaging device, preferably a magnetic resonance (MR) scanner； using the medical imaging device to measure the subject's liver for extracellular fluid； measuring the liver for iron content, in particular for iron overload； determining whether iron overload may be indicated or present from the measurement for iron content, and if indicated correcting the measurement for extra cellular fluid； measuring the liver for hepatic lipid content (HLC)； and determining from said measurements the presence or absence of liver disease. The measurement of the liver for extracellular fluid (ECF) content in conjunction with concurrent interpretation of lipid and iron content provides robust, rapid non-invasive diagnosis of the type and/or severity of many common liver diseases, such as NAFLD/NASH, hepatitis, and iron overload.
