Jonathan H. LeBowitz,Stephen M. Beverley,William S. Sly
申请号：
US12610596
公开号：
US08207114B2
申请日:
2009.11.02
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
