A medicine storage apparatus includes a cassette having an inlet-outlet opening for delivering/receiving items of medicine therethrough and adapted to store items of medicine arranged in array while a force is applied to the items of medicine toward the inlet-outlet opening a support mechanism for supporting the cassette while the inlet-outlet opening is exposed and a counting mechanism for counting the number of items of medicine stored in the cassette. A user takes out items of medicine stored in the cassette from the inlet-outlet opening in an arrayed sequence when the medicine is to be used. Among the delivered items of medicine, unused items of medicine are pushed back into the cassette from the inlet-outlet opening.