PROBLEM TO BE SOLVED: To provide a therapeutic and diagnostic method associated with undesired angiogenesis, wherein, there are a number of diseases known to be associated with undesired angiogenesis, including, ocular neovascularization, such as retinopathies including diabetic retinopathy, age-related macular degeneration, psoriasis, hemangioblastoma, hemangioma, arteriosclerosis, inflammatory disease, such as a rheumatoid or rheumatic inflammatory disease, especially arthritis including rheumatoid arthritis, or other chronic inflammatory disorders, such as chronic asthma, arterial or post-transplantational atherosclerosis, endometriosis, and neoplastic diseases, for example so-called solid tumors and liquid (or hematopoietic) tumors such as leukemias and lymphomas.SOLUTION: Provided are specific binding agents, that bind to angiopoietin-2, such as fully human antibodies, heavy chain fragments, light chain fragments and CDRs of the antibodies, as well as methods of making and using the antibodies.COPYRIGHT: (C)2010,JPO&INPIT【課題】望ましくない血管形成に関連している病気は多数あり、眼血管新生、例えば糖尿病性網膜症を含めた網膜症及び老人性黄斑変性;乾癬;血管芽腫;血管腫;動脈硬化症;炎症性疾患、例えばリウマチ様またはリウマチ性炎症性疾患、特に関節リウマチを含めた関節炎、または他の慢性炎症性疾患、例えば慢性喘息;動脈または移植後アテローム性動脈硬化症;子宮内膜症;並びに新生物疾患、例えば所謂充実性腫瘍及び流動性(または、造血性)腫瘍、例えば白血病またはリンパ腫が含まれ、望ましくない血管形成に関連する疾患の治療、診断方法を提供する。【解決手段】アンギオポエチン-2に結合する特異的結合剤、例えば完全ヒト抗体、抗体の重鎖断片、軽鎖断片及びCDR。抗体の作成及び使用方法。【選択図】なし
