您的位置: 首页 > 农业专利 > 详情页

COMBINED TREATMENT OF CHRONIC OBSTRUCTIVE LUNG DISEASE
专利权人:
КЬЕЗИ ФАРМАЧЕУТИЧИ С.П.А. (IT)
发明人:
БОНЕЛЛИ Сауро (IT),УСБЕРТИ Франческа (IT),ДЗАМБЕЛЛИ Энрико (IT)
申请号:
RU2012125966/15
公开号:
RU2012125966A
申请日:
2010.12.22
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A pharmaceutical composition for the prevention or treatment of COPD, comprising: (a) glycopyrronium chloride; and (b) formoterol or a salt thereof; dissolved in an HFA propellant or in a mixture of an HFA propellant with a co-solvent, adding 1M HCl to the composition in an amount of 0.1-0.3 μg / μl of the composition. 2. The composition of claim 1, wherein the amount of 1M HCl is 0.15 to 0.28 μg / μl. The pharmaceutical composition according to claim 1, wherein the cosolvent is ethanol. The pharmaceutical composition according to any one of the preceding claims, which further comprises one or more pharmaceutically active ingredients selected from the group consisting of beta agonists, corticosteroids, antimuscarinic agents and phosphodiesterase (IV) inhibitors. 5. The pharmaceutical composition according to claim 4, comprising beclomethasone dipropionate. The pharmaceutical composition according to claim 5, wherein the concentration of (a) glycopyrronium chloride is in the range of 0.005-0.83% w / w. The pharmaceutical composition according to claim 6, wherein the concentration (b) of formoterol or its salt is in the range of 0.005-0.07% w / w. The pharmaceutical composition of claim 1, wherein the oxygen has been substantially removed by purging. The pharmaceutical composition of claim 4, wherein the oxygen has been substantially removed by purging. An aerosol container containing a pharmaceutical composition according to any one of claims 1 to 8.11. The container of claim 10, from which oxygen has been substantially removed from the space above the pharmaceutical composition contained therein. The method of filling the container according to claim 10 or 11, comprising the steps of: a) obtaining a solution of glycopyrronium chloride, formoterol fumarate and, optionally, beclomethasone dipropionate in a co-solvent, to which1. Фармацевтическая композиция для предупреждения или лечения ХОЗЛ, включающая:(a) гликопиррония хлорид; и(b) формотерол или его соль;раствор
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充