An image reconstruction method is described as follows. A structural image of an object is obtained. A practically optical detected result of the object is obtained. A inhomogeneous initial state is determined based on the structural image. At least one solution converged to the practically optical detected result is determined by iteratively calculating a physical model from the inhomogeneous initial state. The image of the object is reconstructed based on the solution.一種影像重建方法如下所述。取得一目標物之一結構性影像。取得目標物之一實際光學偵測結果。根據結構性影像,給定一非均勻初始狀態。從非均勻初始狀態出發,疊代計算一物理模型,尋求與實際光學偵測結果收斂的至少一解。根據疊代計算之解,重建目標物之影像。101-109...步驟