A heart valve prosthesis (1) configured to be implanted at cardiac valve annulus located at an interface between a ventricle (LV) and an atrium (LA), the heart valve prosthesis (1) including:- a first portion (2) configured for enclosing a plurality of chordae tendineae (CT) in the ventricle (LV) and native valve leaflets (NVL) to which said chordae tendineae are connected, and- a second portion (4) including a radially expandable annular member (6) and a prosthetic heart valve (8) anchored to said radially expandable annular member (6),wherein said first portion (2) is configured to be implanted in the ventricle (LV), andwherein said second portion (4) is configured to be implanted and coupled to the first portion (2) at the cardiac valve annulus.
