DR GOVERDHAN PUCHCHAKAYALA,DR KRISHNA MOHAN GOTTUMUKKALA
申请号：
IN2309/CHE/2014
公开号：
IN2014CH02309A
申请日:
2014.05.09
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention relates to novel extract for controlling hyperglycaemia and hyperlipidaemia and use for management of diabetes. Aim of the study: To determine the effectiveness of Muntingia calabura (MC) extract as an antidiabetic agent in vitro and in vivo. Preparation of Extract: Methanolic extract and fractions of Muntingia calabura. Method: Hypoglycemic effect in normal and antihyperglycemic activity in diabetic rats, rat hemi-diaphragm, cell line(3T3-Ll cells and RIN cells) Results: The extract increased glucose uptake in 3T3-L1 cells, they have potential antihyperglycaemic , antihyperlipidaemic effects, No toxic effect was observed after 28 days treatment as evident from normal liver, In invitro study, Ethyl acetate fraction of MC (EAFMC) exhibited a concentration dependent free radical scavenging activity. In sub acute study in streptozotocin induced diabetic rats, EAFMC showed antioxidant activity by significantly decreasing the level of lipidperoxidative marker, malondialdehyde (MDA), a protective action against cell damage required in diabetes therapy. Conclusions: Muntingia calabura extract has effects that enhance glucose uptake and provide the basis for antidiabetic activity of the extract.
