Peter DRAGOVICH,Zhonghua PEI,Thomas PILLOW,Jack SADOWSKY,Vishal VERMA,Donglu ZHANG
申请号：
US16689286
公开号：
US20200085965A1
申请日:
2019.11.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.
