IAP抑制劑和溶瘤病毒在製備抗腫瘤藥物中的應用农业专利-农业专业知识服务系统

发明人:: YAN, GUANGMEI,颜光美,顏光美,CAI, JING,蔡静,蔡靜,LIN, YUAN,林园,林園,ZHANG, HAIPENG,张海鹏,張海鵬,LIN, SUIZHEN,林穗珍,GONG, SHOUFANG,龚守芳,龔守芳,HU, JUN,胡骏,胡駿,XIAO, XIAO,肖晓,肖曉,LI, KAI,李凯,李凱,LIANG, JIANKAI,梁剑开,梁劍開,TAN, YAQIAN

摘要：: Described herein is use of a Caspase activator and an oncolytic virus in the preparation of an anti-tumor drug. As described, Caspase activator can enhance the anti-tumor effect of oncolytic virus, and the combination of Caspase activator and oncolytic virus produces a significant synergistic anti-tumor effect, and demonstrates an effective therapy for the treatment of tumors that are less sensitive to other pharmaceutical treatments.本發明屬於生物醫藥領域，涉及Caspase活化劑與溶瘤病毒的聯用在製備抗腫瘤藥物中的應用。本發明首次發現Caspase活化劑可以增加溶瘤病毒的抗腫瘤效應，兩者聯用起到極強的協同性作用，對用藥敏感性不高的腫瘤治療來說提供了一個有效的治療方案。