AL HUSBAN, Farhan Abdel Karim Mohammad,GLAD, Lars Håkan Christer,HALLSTEIN, Jenny Malin Christina,MOIR, Andrea Jane,THOMPSON, Michael Peter
申请号：
PE2018002028
公开号：
PE20190372A1
申请日:
2017.04.20
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
1. Oral disintegrating tablets, containing a formula compound: this compound is conventionally called (1s, 2S, 3R, 5S) - 3 - [7 - [(1R, 2S) - 2 - (3, 4-difluorophenyl) cycloacrylonitrile] - 5 - (propyl) 3 - [1, 2, 3] - triazole - [4, 5-d] pyridin-3-il] - 5 - (2-As part of the compression (preferably between 12-17% of the total weight), add a separate precursor (which may be a unique substance such as cropovino, croscaremosa sodica, microcrystalline cellulose, etc.), or a mixture, known as a pre heteromorphic premix, to make multiple These are at least one carbohydrate filler, at least one decomposition, in sufficient quantities (in the case of mixtures, between 50% and 80%).There is an agent that can be used (preferably a proliferation step is required in this process, accounting for 0.5-1% of the total weight).One or more lubricants (1-3% of total weight)Preservatives, stabilizers and / or antioxidants, compression hardness of about 50 n-150 n, decomposition time less than 3 minutes (preferably less than 60 seconds). It also refers to manufacturing processes, treatment and prevention methods, and blister type packaging. The present invention is useful for the treatment or prevention of animal and plant diseases in patients with cardiovascular disease and stent's thrombosis, as well as in patients with bleeding who need this compound.Se refiere a comprimidos de disgregacion oral, que contiene un compuesto de formula I: Este compuesto se denomina de forma convencional (1S, 2S, 3R, 5S)-3-[7-{[(1R, 2S)-2-(3, 4-difluorofenil)ciclopropil]amino}-5-(propiltio)-3H-[1, 2, 3]-triazolo-[4, 5-d]pirimidin-3-il]-5-(2-hidroxietoxi)ciclopentano-1, 2-diol (tambien se denomina ticagrelor)； formando parte del comprimido (preferentemente en una cantidad entre 12%-17% aproximadamente del peso total) junto a un excipiente disgregante (puede ser una unica sustancia como crospovidona, croscarmelosa sodica, celulosa microcristalina, entre otros, o una mezcla de sustancias denominada preme
